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Related Experiment Video

Updated: Jun 16, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

[Cytokines in systemic sclerosis].

J Baraut¹, D Farge, F Jean-Louis

¹hôpital Saint-Louis. pavillon Bazin, Paris, France.

Pathologie-Biologie

|February 2, 2010

Summary

This summary is machine-generated.

The balance of T-helper (Th) cell cytokines is crucial in systemic sclerosis (SSc) pathogenesis. Targeting this cytokine imbalance offers potential new therapeutic strategies for SSc.

Related Experiment Videos

Last Updated: Jun 16, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Area of Science:

Immunology
Pathophysiology
Molecular Biology

Context:

Systemic sclerosis (SSc) pathogenesis involves a critical imbalance in T-helper (Th) cell cytokine profiles.
The Th2 cytokine response, marked by elevated IL-4, IL-10, and TGF-β, is strongly linked to the fibrotic tissue remodeling characteristic of SSc.
Cytokine levels are recognized as significant diagnostic and prognostic biomarkers in SSc patients, detectable in blood and tissue samples.

Purpose:

To elucidate the role of T-helper cell cytokine balance in systemic sclerosis (SSc) pathogenesis.
To highlight the significance of Th2-mediated fibrosis and the potential of cytokine analysis as biomarkers.
To explore the therapeutic implications of restoring Th1/Th2/Th17/Treg balance in SSc.

Summary:

The pathogenesis of systemic sclerosis (SSc) is significantly influenced by the dysregulation of T-helper (Th) cell cytokine production, including Th1, Th2, Th17, and regulatory T (Treg) cells.
A predominant Th2 cytokine response, characterized by increased Interleukin-4 (IL-4), Interleukin-10 (IL-10), and Transforming Growth Factor-beta (TGF-β), directly contributes to the fibrotic tissue changes observed in SSc.
Monitoring cytokine profiles in SSc patients serves as a vital tool for diagnosis and prognosis.

Impact:

Understanding the cytokine milieu in SSc can lead to the development of novel diagnostic and prognostic tools.
Restoring the balance of Th1/Th2/Th17/Treg cells is a promising therapeutic avenue for SSc treatment.
Cytokine modulators represent a potential class of drugs for future SSc therapeutic strategies.