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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

492
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
492
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

303
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
303
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

464
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
464
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

390
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
390
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

884
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
884
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

364
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
364

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Related Experiment Video

Updated: Jul 28, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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[Gastrointestinal tract involvement in systemic sclerosis].

A Renaud1, A Jirka2, C Durant1

  • 1Service de médecine interne, Nantes université, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.

La Revue De Medecine Interne
|June 3, 2023
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis frequently affects the gastrointestinal tract, causing malnutrition and impacting quality of life. Management requires a multidisciplinary approach, with ongoing research aiming for better diagnostic and therapeutic tools.

Keywords:
Chronic intestinal pseudo-obstructionColonisation bactérienne chronique du grêleEctasie vasculaire antrale gastriqueGastric antral vascular ectasiaGastroesophageal reflux diseasePseudo-obstruction intestinale chroniqueReflux gastro-œsophagienSclérodermie systémiqueSmall intestinal bacterial overgrowthSystemic sclerosis

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Area of Science:

  • Gastroenterology
  • Rheumatology
  • Internal Medicine

Context:

  • Systemic sclerosis (SSc) is a multisystem autoimmune disease.
  • Gastrointestinal (GI) tract involvement is highly prevalent in SSc, affecting over 90% of patients.
  • GI manifestations in SSc are diverse and can significantly impair patient health.

Purpose:

  • To review the complex gastrointestinal manifestations of systemic sclerosis.
  • To highlight the challenges in managing SSc-related GI dysfunction and malnutrition.
  • To discuss current and future therapeutic strategies for improving patient outcomes.

Summary:

  • Gastrointestinal tract involvement in systemic sclerosis is nearly universal, presenting with varied clinical symptoms.
  • This involvement frequently leads to multifactorial malnutrition, a major cause of reduced quality of life and potential mortality.
  • Current management is complex, involving dietary changes, medications like proton pump inhibitors and prokinetics, and interventional procedures, often with side effects.

Impact:

  • Improved understanding of the broad spectrum of GI issues in systemic sclerosis.
  • Highlights the critical need for multidisciplinary care in managing these complex patients.
  • Emphasizes the potential for novel diagnostic and therapeutic advancements to enhance prognosis and quality of life.