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Related Experiment Video

Updated: Jun 16, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Severe hypothyroidism presenting as obstructive sleep apnea.

¹Children's Hospital Boston, MA, USA. dennis.rosen@childrens.harvard.edu,

Clinical Pediatrics

|February 2, 2010

Summary

Children with Down syndrome (DS) and obstructive sleep apnea (OSA) may have underlying hypothyroidism. Treating this thyroid condition led to full resolution of OSA in a 5-year-old patient.

Area of Science:

Pediatrics
Endocrinology
Sleep Medicine

Background:

Down syndrome (DS) is associated with an increased risk of obstructive sleep apnea (OSA).
Thyroid dysfunction, particularly hypothyroidism, is also more prevalent in children with DS.

Observation:

A 5-year-old child with Down syndrome presented with mild to moderate obstructive sleep apnea.
The child was subsequently diagnosed with severe hypothyroidism.

Findings:

Treatment with levothyroxine for 3 months resulted in the complete resolution of obstructive sleep apnea.
This case highlights a potential causal link between hypothyroidism and OSA in children with DS.

Implications:

Routine thyroid function screening is crucial for children with Down syndrome, especially those with OSA.

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Identifying and treating hypothyroidism can lead to the resolution of obstructive sleep apnea in this population.

This approach may offer a targeted therapy for OSA beyond standard treatments in children with DS.