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Detecting the conformation of individual proteins in live cells

John J Sakon1, Keith R Weninger

  • 1Department of Physics, North Carolina State University, Raleigh, North Carolina, USA.

Nature Methods
|February 2, 2010
PubMed

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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...