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Related Concept Videos

Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
UV–Vis Spectroscopy: Beer–Lambert Law01:09

UV–Vis Spectroscopy: Beer–Lambert Law

The Beer-Lambert law describes the relationship between absorbance and concentration, which combines the principles established by scientists Johann Heinrich Lambert and August Beer. Lambert's law states that when light passes through a medium, the loss in intensity is directly proportional to the original intensity and the path length of the light. Beer's law proposed that the transmittance of a solution remains constant if the product of concentration and path length is constant. The modern...
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

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On...
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
Adsorption Isotherms II01:25

Adsorption Isotherms II

Brunauer, Emmett, and Teller (BET) introduced a theory in 1938 that modified Langmuir's assumptions to explain multilayer physical adsorption. This theory is applicable to Type II isotherms and provides a more realistic picture of adsorption processes. The BET theory assumes a uniform solid surface with localized adsorption sites, where adsorption at one site doesn't affect adsorption at neighboring sites. This theory also allows for the possibility of additional molecules being adsorbed on top...

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Updated: Jun 16, 2026

Characterization of Biological Absorption Spectra Spanning the Visible to the Short-Wave Infrared
07:38

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Published on: January 10, 2025

Determination of low bulk absorption coefficients.

H H Witte

    Applied Optics
    |February 2, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Accurately measuring glass fiber absorption losses is crucial. A novel method uses surface temperature rise to determine absorbed radiation power, offering superior precision over traditional techniques.

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    Area of Science:

    • Materials Science
    • Optical Engineering
    • Thermodynamics

    Background:

    • Low-loss glass fiber production requires precise knowledge of bulk material absorption.
    • Conventional methods for measuring absorption losses can be inaccurate due to changing emissivities.
    • Accurate absorption coefficient determination is vital for advanced optical material development.

    Purpose of the Study:

    • To develop a novel, highly accurate method for determining absorption losses in bulk materials for glass fiber production.
    • To establish a theoretical relationship between absorbed radiation power and surface temperature rise.
    • To minimize errors caused by radiative heat transfer in absorption measurements.

    Main Methods:

    • Deriving the relationship between absorption coefficient (alpha) and surface temperature rise (DeltaT(R)).
    • Calculating optimal sample and thermocouple dimensions to minimize thermal radiation effects.
    • Utilizing temperature rise at the material surface to quantify absorbed radiation power (L(a)).

    Main Results:

    • The derived relationship allows for precise calculation of absorption coefficient from temperature measurements.
    • Optimized sample and thermocouple dimensions effectively eliminate errors from sample and wire thermal radiation.
    • The proposed method demonstrates a significant improvement in accuracy, orders of magnitude better than conventional techniques.

    Conclusions:

    • The novel method provides a highly accurate and reliable way to measure absorption losses in bulk materials.
    • Eliminating radiative heat transfer is critical for precise absorption coefficient determination.
    • This technique offers a substantial advancement over existing methods for optical fiber material characterization.