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Plasma adrenocorticotropin levels in normal dogs.
American Journal of Veterinary Research
|October 1, 1977
Summary
Normal dogs have an average plasma adrenocorticotropin (ACTH) concentration of 45.77 pg/ml. This measurement can help diagnose canine adrenal cortical disorders.
Area of Science:
- Veterinary Medicine
- Endocrinology
- Canine Physiology
Background:
- Adrenocorticotropin (ACTH), also known as corticotropin, is a hormone produced by the anterior pituitary gland.
- ACTH plays a crucial role in regulating the adrenal cortex.
- Disorders of the adrenal cortex in dogs can lead to significant health issues.
Purpose of the Study:
- To establish reference plasma concentrations of ACTH in healthy, resting dogs.
- To provide baseline data for diagnosing canine adrenal disorders.
Main Methods:
- Blood samples were collected from 31 healthy adult dogs at rest.
- Plasma ACTH concentrations were measured using a validated assay.
Main Results:
- The mean plasma ACTH concentration in normal dogs was 45.77 pg/ml.
- Individual ACTH values ranged from 17 to 98 pg/ml.
Conclusions:
- The established reference range for plasma ACTH can aid in the diagnosis of primary and secondary spontaneous canine adrenal cortical disorders.
- Accurate ACTH measurement is valuable for veterinary endocrinology and diagnosing pituitary-adrenal axis dysfunction.