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[Expression of transferrin receptor on transitional cell cancer]
Y Tomita1, T Nishiyama, S Sato
1Department of Urology, Niigata University School of Medicine.
Hinyokika Kiyo. Acta Urologica Japonica
|January 1, 1991
Summary
Transferrin receptor (TR) expression is elevated in transitional cell cancer (TCC), correlating with higher tumor grade and invasiveness. Detecting TR aids in assessing TCC malignancy and recurrence risk.
Area of Science:
- Oncology
- Immunohistochemistry
- Molecular Biology
Context:
- Transitional cell cancer (TCC) is a significant cause of morbidity and mortality.
- Understanding tumor markers is crucial for accurate diagnosis and prognosis.
- The role of transferrin receptor (TR) in TCC progression requires further elucidation.
Purpose:
- To investigate the expression of transferrin receptor (TR) in TCC using immunohistological methods.
- To determine the correlation between TR expression and tumor malignancy, grade, and invasiveness.
- To assess the utility of TR detection in predicting tumor recurrence.
Summary:
- Transferrin receptor (TR) was immunohistochemically examined in 51 TCC samples.
- TR was detected in 48 out of 51 TCC tumors, but not in normal transitional epithelium.
- Higher TCC grade and invasiveness were associated with more frequent and intense TR expression.
- Recurrent TCC showed significantly higher TR expression compared to initial tumors.
Impact:
- TR expression serves as a valuable biomarker for estimating the degree of TCC malignancy.
- TR detection can potentially aid in risk stratification and treatment planning for TCC patients.
- This study highlights TR as a potential therapeutic target in TCC.