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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

[Oxidative stress in multiple sclerosis].

Elzbieta Miller1, Małgorzata Mrowicka, Krystian Zołyński

  • 1III Ogólny Szpital w Łodzi, Oddział Rehabilitacji. betty.miller@interia.pl

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

Oxidative stress from reactive oxygen species contributes to multiple sclerosis (MS) pathogenesis. Antioxidant therapies may protect against tissue damage and improve neurological outcomes in MS patients.

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

Area of Science:

  • Neuroimmunology
  • Oxidative Stress Research

Context:

  • Multiple sclerosis (MS) pathogenesis involves significant oxidative stress (OS).
  • Reactive oxygen species (ROS), primarily from macrophages, mediate demyelination and axonal damage in MS.
  • The central nervous system (CNS) is vulnerable to ROS due to high oxygen demand and low antioxidant levels.

Purpose:

  • To explore the role of oxidative stress in multiple sclerosis.
  • To investigate the potential therapeutic benefits of antioxidants in MS treatment.

Summary:

  • Excess ROS generated by macrophages cause cellular damage (lipids, proteins, nucleic acids), leading to cell death in MS.
  • Compromised antioxidant defenses in the CNS exacerbate ROS-induced damage.
  • Antioxidant treatments, including enzymatic and non-enzymatic compounds, show potential for managing MS and other immune diseases.

Impact:

  • Antioxidant interventions could prevent further tissue damage in MS.
  • Therapeutic strategies targeting ROS may improve patient survival and neurological function.
  • Modulating immune cell function with antioxidants offers a potential approach for MS prevention and treatment.