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Related Experiment Videos

Infectious keratitis and cyanoacrylate adhesive.

T B Cavanaugh1, J D Gottsch

  • 1Cornea Service, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

American Journal of Ophthalmology
|April 15, 1991
PubMed
Summary

Cyanoacrylate glue for infectious keratitis can mask serious infections, leading to complications like bacterial or fungal ulcers and the need for corneal transplants. Careful consideration of risks is essential.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Corneal Surgery

Background:

  • Cyanoacrylate glue is used in ophthalmology, but its potential complications are not fully understood.
  • Infectious keratitis is a serious condition that can lead to vision loss.
  • Prophylactic antibiotic therapy may not always prevent infections associated with ocular procedures.

Observation:

  • Three cases of infectious keratitis after cyanoacrylate gluing are presented.
  • Two cases involved bacterial ulcers (MRSA, H. influenzae), one fungal.
  • Opaqueness of glue masked infection and perforation; pain was possibly obscured.

Findings:

  • Infections occurred despite prophylactic antibiotics.
  • Two patients required penetrating keratoplasty.

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  • Glue-related corneal infections can be severe and sight-threatening.

    • Implications:

    • Consider tissue toxicity, microbial colonization, bandage lenses, and long-term antibiotics as risk factors.
    • Masking of infection and development of resistant organisms are key concerns.
    • Careful patient selection and monitoring are crucial when using cyanoacrylate adhesives.