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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

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Malocclusion in aging Wistar rats.

Ismene A Dontas1, Apostolos I Tsolakis, Lubna Khaldi

  • 1Laboratory for Research of the Musculoskeletal System, School of Medicine, University of Athens, Athens, Greece. idontas@med.uoa.gr

Journal of the American Association for Laboratory Animal Science : JAALAS
|February 4, 2010
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Rodent incisor malocclusion, or dental overgrowth, can cause severe health issues and death. Increased incidence in Wistar rats suggests aging or genetic factors, necessitating attention in long-term studies.

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Area of Science:

  • Veterinary Science
  • Rodent Health
  • Animal Welfare

Background:

  • Insufficient wear of rodent incisors leads to malocclusion and rapid tooth elongation.
  • This condition can go undetected, negatively impacting animal welfare and potentially causing death.
  • Dental overgrowth can result in undernutrition and trauma to surrounding tissues.

Purpose of the Study:

  • To describe the increased incidence of malocclusion in Wistar rats during a longitudinal growth and aging study.
  • To investigate potential causes of malocclusion, including environmental, aging, and genetic factors.
  • To highlight the importance of monitoring for malocclusion in long-term rodent research.

Main Methods:

  • Longitudinal study of Wistar rat growth and aging.
  • Observation and documentation of malocclusion incidence.
  • Histologic examination of the temporomandibular joint in affected animals.

Main Results:

  • An increased incidence of malocclusion was observed in the studied Wistar rat population.
  • Histologic examination revealed no inflammatory or degenerative changes in the temporomandibular joint.
  • No environmental factors were identified as causative agents for the malocclusion.

Conclusions:

  • Aging or genetic factors are considered the likely causes of malocclusion in this study.
  • Malocclusion can adversely affect rodent health and wellbeing.
  • Special attention should be given to the potential appearance of malocclusion during long-term rodent studies.