Related Experiment Video
Updated: Jun 16, 2026
08:02
Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
Endogenous steroid profiling in the athlete biological passport
Pierre-Edouard Sottas1, Martial Saugy, Christophe Saudan
1Swiss Laboratory for Doping Analyses, University Center of Legal Medicine, West Switzerland, Epalinges, Switzerland. Pierre-Edouard.Sottas@chuv.ch
Endocrinology and Metabolism Clinics of North America
|February 4, 2010
Summary
The Athlete Steroidal Passport (ASP) deters steroid doping by monitoring hormone levels and genetic factors. It helps identify doping and has potential clinical applications in endocrinology.
Area of Science:
- Sports Science
- Endocrinology
- Anti-doping
Background:
- The Athlete Biological Passport (ABP) monitors athlete biomarkers.
- The Athlete Steroidal Passport (ASP) is an endocrine module of the ABP.
- ASP detects steroid doping and indirect doping strategies.
Purpose of the Study:
- To detail the development and application of the Athlete Steroidal Passport (ASP).
- To highlight ASP's role in deterring steroid doping in elite sports.
- To explore ASP's potential clinical applications in endocrinology.
Main Methods:
- Utilizes a comprehensive dataset of endogenous steroidal hormones in urine.
- Incorporates athlete-specific reference ranges and genetic factors (e.g., UGT2B17 genotype).
- Accounts for confounding factors like alcohol consumption and employs Bayesian inference for evidence evaluation.
Main Results:
- ASP effectively identifies direct and indirect steroid doping methods.
- ASP enables targeted testing (GC/C/IRMS) and temporary athlete withdrawal.
- ASP provides a robust system for anti-doping rule violations when abnormalities are unexplained.
Conclusions:
- The ASP is a valuable tool for deterring steroid doping in elite sports.
- ASP's methodology offers a robust framework for ensuring fair competition.
- The ASP has straightforward applications in evidence-based endocrinology practice.
Related Concept Videos
01:31Internal Receptors
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
01:08Intracellular Hormone Receptors
Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell