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Related Concept Videos

Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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Related Experiment Video

Updated: Jun 16, 2026

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
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Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

Published on: October 26, 2016

Drug eluting balloons.

Nicolas A Diehm1, Hanno Hoppe, Dai-Do Do

  • 1Division of Clinical and Interventional Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, Bern, Switzerland. diehm@gmx.ch <diehm@gmx.ch>

Techniques in Vascular and Interventional Radiology
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

Drug-eluting balloons offer a promising solution to prevent restenosis, a common issue after percutaneous transluminal angioplasty (PTA) in lower limb interventions. This review explores their clinical utility in improving vessel patency.

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A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
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Published on: September 19, 2016

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Restenosis remains a significant challenge following percutaneous transluminal angioplasty (PTA), despite advancements like nitinol stents.
  • Previous strategies including systemic medications and endovascular brachytherapy have yielded limited success in preventing restenosis.
  • Drug-eluting stents have also shown limited efficacy in inhibiting restenosis within the femoropopliteal segment.

Purpose of the Study:

  • To review the clinical utility of drug-eluting balloons (DEBs) for lower limb endovascular interventions.
  • To evaluate the effectiveness of DEBs in preventing restenosis after PTA.
  • To highlight DEBs as a novel technology for improving vessel patency in peripheral arterial disease.

Main Methods:

  • Review of existing clinical trials and studies on drug-eluting balloons in lower limb angioplasty.
  • Analysis of data on restenosis rates and target lesion revascularization in patients treated with DEBs.
  • Comparison of DEB efficacy with traditional PTA, stenting, and other anti-restenotic strategies.

Main Results:

  • Drug-eluting balloons have demonstrated clinical efficacy in reducing restenosis in coronary arteries and the femoropopliteal segment.
  • The sustained release of antiproliferative agents, such as paclitaxel, is a key mechanism for inhibiting neointimal hyperplasia.
  • DEBs represent a promising approach to overcome the limitations of current treatments for lower limb arterial disease.

Conclusions:

  • Drug-eluting balloons are a novel and effective technology for inhibiting restenosis after PTA in lower limb interventions.
  • Their proven efficacy in other vascular beds suggests significant potential for improving outcomes in femoropopliteal and below-the-knee interventions.
  • Further research and clinical adoption of DEBs are warranted to optimize their use in managing peripheral arterial disease.