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Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
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The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
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[Intravesical instillations in the elderly subject].

Laurent Guy1, H Quintens, C Pfister

  • 1Service d'urologie, Hôpital Gabriel Montpied, CHU de Clermont-Ferrand, BP 69, 63003 Clermont-Ferrand, France. lguy@chu-clermontferrand.fr

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|February 4, 2010
PubMed
Summary

Intravesical instillations treat bladder tumors but aren't tailored to patient age or health. Treatment should balance tumor risk with individual patient factors for better outcomes.

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Area of Science:

  • Uro-oncology
  • Neoadjuvant therapies
  • Bladder cancer management

Context:

  • Intravesical instillations are standard for non-muscle-invasive bladder cancer (intermediate- to high-risk).
  • Current treatment guidelines lack personalization regarding patient age and comorbidities.
  • Evidence-based adaptation of intravesical therapy is needed.

Purpose:

  • To evaluate the need for adapting intravesical instillation protocols.
  • To align treatment indications with patient-specific physiological age and comorbidities.
  • To optimize bladder cancer management strategies.

Summary:

  • Intravesical instillations are indicated for specific bladder tumor types.
  • Existing indications do not account for patient age and comorbidities.
  • Personalized treatment approaches considering tumor risk and patient factors are recommended.

Impact:

  • Potential to improve treatment efficacy for non-muscle-invasive bladder cancer.
  • Reduced risk of adverse events by tailoring therapy to individual patients.
  • Enhanced clinical decision-making for urologic oncologists.