Related Experiment Video
Updated: Jun 16, 2026
11:54
Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
[Urologic aspects of Polyomavirus infection]
M Thoulouzan1, M Courtade-Saidi, N Kamar
1Service d'urologie, andrologie et transplantation rénale, CHU de Rangueil, TSA 50032, 31059 Toulouse cedex 9, France. thoulouzan.m@chu-toulouse.fr
Summary
Human polyomaviruses, JC virus (JCV) and BK virus (BKV), establish lifelong infections. While typically latent, they can cause disease in immunocompromised individuals and may link to human cancers.
Area of Science:
- Virology
- Oncology
- Immunology
Context:
- Human polyomaviruses (JCV and BKV) are ubiquitous, establishing persistent infections post-adolescence.
- These viruses exhibit specific tissue tropism, primarily affecting renal, urothelial, B, and brain cells.
- Reactivation, particularly of BKV, is a concern in immunosuppressed patients.
Purpose:
- To elucidate the biology of human polyomaviruses (JCV and BKV).
- To review the non-malignant and malignant potentials of these viruses.
- To discuss current therapeutic strategies and management of polyomavirus infections.
Summary:
- JC virus (JCV) and BK virus (BKV) are common human polyomaviruses with lifelong persistence.
- They infect specific tissues and can cause disease, especially in immunocompromised individuals.
- Their association with cancers in animal models suggests a potential etiological role in human malignancies.
Impact:
- Provides a comprehensive overview of human polyomavirus biology and clinical significance.
- Highlights the potential role of polyomaviruses in human cancers, warranting further investigation.
- Informs therapeutic management strategies for polyomavirus infections, particularly in vulnerable populations.
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