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Localized scleroderma and zinc: a pilot study.

Anabelle Brocard1, Gaelle Quereux, Dominique Moyse

  • 1Unit of skin cancer, Nantes University Hospital, Place Alexis Ricordeau 44093 Cedex 01 Nantes, France.

European Journal of Dermatology : EJD
|February 4, 2010
PubMed
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High-dose zinc gluconate shows promise for treating localized scleroderma (morphea) when other treatments fail. This study found a 53% efficacy rate with good tolerability, suggesting it as a potential alternative therapy.

Area of Science:

  • Dermatology
  • Rheumatology
  • Pharmacology

Background:

  • Localized scleroderma (morphea) can cause significant aesthetic and functional issues.
  • Existing treatments for morphea often have limited efficacy.
  • There is a need for effective and well-tolerated therapeutic options.

Purpose of the Study:

  • To assess the effectiveness of high-dose zinc gluconate in treating morphea.
  • To evaluate the tolerability of zinc gluconate in patients with localized scleroderma.

Main Methods:

  • Retrospective study of 17 patients with histologically confirmed active morphea.
  • Patients had previously failed treatment with high-potency dermocorticosteroids.
  • Treatment involved daily administration of 60-90 mg of elemental zinc (as zinc gluconate).

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  • Clinical evaluation by both physician and patient assessment.

    • Main Results:

    • An overall efficacy of 53% was observed.
    • This included 5 partial remissions and 4 complete remissions.
    • The mean daily dose of zinc was 83.3 mg.
    • Two patients (11.8%) experienced epigastric pain, but no treatment discontinuations due to poor tolerability occurred.

    Conclusions:

    • High-dose zinc gluconate may be a valuable alternative treatment for localized scleroderma.
    • The treatment demonstrated good tolerability in the study population.
    • Further placebo-controlled studies are required to validate these findings.