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Updated: Jun 16, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

[Gonadotrophic axis dysfunction in men with HIV-infection/aids].

Clarisse Mourão Melo Ponte¹, Maria Helane Costa Gurgel, Renan Magalhães Montenegro

¹Ambulatório de Distúrbios Endócrino-Metabólicos em HIV/Aids, Hospital São José de Doenças Infecciosas, Secretaria de Saúde do Estado do Ceará.

Arquivos Brasileiros De Endocrinologia E Metabologia

|February 4, 2010

Summary

HIV infection can cause gonadotrophic axis dysfunction in men, leading to low testosterone. Testosterone replacement therapy can improve body composition, bone density, and quality of life in these patients.

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Last Updated: Jun 16, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners

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Published on: June 30, 2013

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

Published on: July 6, 2014

Area of Science:

Endocrinology
Infectious Diseases
Men's Health

Context:

Gonadotrophic axis dysfunction is prevalent in HIV-infected individuals.
Pathogenesis involves multifactorial causes including viral effects, medications, and comorbidities.
Low testosterone (hypogonadism) in men with HIV is linked to adverse health outcomes.

Purpose:

To review current epidemiologic data on male gonadotrophic axis abnormalities in HIV.
To discuss the pathophysiology of these hormonal imbalances.
To outline treatment strategies for HIV-associated hypogonadism.

Summary:

HIV infection impacts the hypothalamic-pituitary-gonadal axis, frequently causing hypogonadism in men.
Symptoms include loss of muscle mass, decreased bone density, fatigue, and depression.
Testosterone replacement therapy (TRT) offers significant benefits for metabolic profile, body composition, bone health, and psychological well-being.

Impact:

Highlights the importance of monitoring and managing hypogonadism in HIV-infected men.
Provides an update on therapeutic interventions for improving patient outcomes.
Emphasizes the role of TRT in enhancing the quality of life for affected individuals.