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Published on: April 14, 2016
Propoxyphene and pain management in the elderly
Jane R Mort1, Stephan D Schroeder
1South Dakota State University College of Pharmacy, USA.
Summary
Propoxyphene is not more effective than acetaminophen (APAP) for elderly pain relief but carries significant risks, including opioid side effects and overdose deaths. Safer alternatives like APAP should be prioritized for pain management in older adults.
Area of Science:
- Geriatrics
- Pain Management
- Pharmacology
Background:
- Pain is prevalent and undertreated in the elderly.
- Concerns exist regarding the efficacy and safety of certain pain medications in this population.
- Propoxyphene has faced scrutiny from regulatory bodies and the medical community.
Purpose of the Study:
- To evaluate the efficacy and safety of propoxyphene in elderly pain management.
- To compare propoxyphene with acetaminophen (APAP) and explore alternative pain relief options.
- To highlight the risks associated with propoxyphene use in older adults.
Main Methods:
- Review of multiple studies comparing propoxyphene and acetaminophen (APAP).
- Analysis of prescription data for propoxyphene/APAP products, including dosage exceedances.
- Examination of propoxyphene prescription prevalence in Medicare populations.
Main Results:
- Propoxyphene demonstrated no superior efficacy compared to acetaminophen (APAP).
- Propoxyphene is associated with opioid side effects and a higher risk of drug-related fatalities.
- A significant percentage of propoxyphene/APAP prescriptions exceeded maximum daily dosage limits.
Conclusions:
- Propoxyphene presents considerable safety concerns for elderly patients.
- Acetaminophen (APAP) and other analgesics are recommended as safer alternatives for pain management in older adults.
- Healthcare providers should carefully consider risks versus benefits when prescribing pain medication to the elderly.
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