Related Experiment Videos

Targeted therapies in osteoarthritis: a systematic review of the trials on www.clinicaltrials.gov

Francis Berenbaum1

  • 1Pierre & Marie Curie University Paris VI, AP-HP Saint-Antoine Hospital, Paris, France. francis.berenbaum@sat.aphp.fr

Best Practice & Research. Clinical Rheumatology
|February 5, 2010
PubMed

Insights

This review summarizes clinical trials for osteoarthritis, focusing on targeted therapies. It covers the safety and efficacy of new treatments for this joint disease.

Area of Science:

  • Rheumatology
  • Clinical Pharmacology

Background:

  • Osteoarthritis (OA) is a prevalent degenerative joint disease.
  • Effective targeted therapies for OA are under active investigation.

Purpose of the Study:

  • To systematically review clinical trials for osteoarthritis registered with the National Institutes of Health (NIH) Clinical Trials Data Bank.
  • To focus on trials evaluating the safety and efficacy of targeted therapies in OA management.

Main Methods:

  • Conducted a systematic review of registered clinical trials.
  • Included trials focused on targeted therapeutic interventions for osteoarthritis.
  • Utilized the NIH Clinical Trials Data Bank for comprehensive trial data.

Main Results:

  • The review encompasses a significant portion of ongoing and upcoming OA clinical trials.
  • Identified trials specifically testing the safety and/or efficacy of targeted OA therapies.

Conclusions:

  • This review provides an overview of current research trends in targeted OA therapies.
  • Highlights the landscape of clinical investigations into novel OA treatments.

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...