Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 16, 2026

Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation
08:28

Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation

Published on: September 13, 2012

Nano-emulsions prepared by the phase inversion composition method: preparation variables and scale up.

Isabel Solè1, Carmen M Pey, Alicia Maestro

  • 1Departament d'Enginyeria Química, Universitat de Barcelona, Martí i Franqués 1, 08028 Barcelona, Spain.

Journal of Colloid and Interface Science
|February 5, 2010
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined Application of Ultra-High-Pressure Homogenization and Non-<i>Saccharomyces</i> Yeasts to Reduce Sulfites and Improve Wine Quality.

Foods (Basel, Switzerland)·2026
Same author

Minimally invasive characterization of peripheral blood measurable residual disease in multiple myeloma using high-sensitivity detection of ctDNA by next-generation sequencing.

HemaSphere·2026
Same author

Real-world pegcetacoplan treatment of paroxysmal nocturnal hemoglobinuria patients with an unsatisfactory response to prior therapies.

Hematology (Amsterdam, Netherlands)·2026
Same author

Shifts in the vaginal microbiota of nulliparous ewe lambs following initial reproductive handling and estrus synchronization.

Journal of animal science·2026
Same author

Phylogeography and population genetics of the white spotted eagle ray, Aetobatus laticeps Gill, 1865, in the Eastern Tropical Pacific.

PloS one·2026
Same author

Pre-harvest melatonin applications improve post-harvest quality of tomato fruits.

Food chemistry·2026

Optimizing nano-emulsion production requires careful control of mixing and vessel geometry. Scale-up is achievable by maintaining addition time and mixing rate, not just dimensionless variables like Reynolds number.

Area of Science:

  • Colloid and Surface Science
  • Materials Engineering
  • Chemical Engineering

Background:

  • Nano-emulsions are critical for various applications, demanding precise control over droplet size and stability.
  • The Phase Inversion Composition (PIC) method is a common technique for nano-emulsion preparation.
  • Understanding scale-up challenges is vital for industrial production.

Purpose of the Study:

  • To investigate the impact of vessel geometry and scale-up on nano-emulsion properties using the PIC method.
  • To determine optimal mixing conditions for achieving small droplet sizes.
  • To evaluate the suitability of dimensionless variables for scale-up.

Main Methods:

  • Experimental design methodology was employed.
  • Nano-emulsions were prepared using the Phase Inversion Composition (PIC) method.

More Related Videos

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Triplet Fusion Upconversion Nanocapsule Synthesis
08:36

Triplet Fusion Upconversion Nanocapsule Synthesis

Published on: September 7, 2022

Related Experiment Videos

Last Updated: Jun 16, 2026

Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation
08:28

Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation

Published on: September 13, 2012

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Triplet Fusion Upconversion Nanocapsule Synthesis
08:36

Triplet Fusion Upconversion Nanocapsule Synthesis

Published on: September 7, 2022

  • The influence of vessel geometry, addition rates, and mixing rates was systematically studied.

    • Main Results:

    • Proper mixing is essential for small droplet-sized nano-emulsions, particularly when free oil and liquid crystal phases coexist.
    • Optimal mixing conditions involve small addition rates and high mixing rates, but excessive mixing can induce coalescence.
    • Scale-up is not adequately described by maintaining the Reynolds number; instead, constant total addition time and linear mixing rate are crucial.
    • The cubic liquid crystal phase (Pm3n) formation, without free oil, prevents coalescence due to high viscosity, but hinders scale-up based on dimensionless variables.

    Conclusions:

    • Vessel geometry and mixing parameters significantly influence nano-emulsion characteristics during PIC preparation.
    • Scale-up requires maintaining specific process parameters like addition time and mixing rate, rather than solely relying on dimensionless numbers.
    • The findings provide critical insights for the industrial production of nano-emulsions with controlled properties.