Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structure of Cardiac Muscles

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Overview of Secretory Vesicles

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...

Cardiomyopathy IV: Restrictive Cardiomyopathy

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

Specialized Characteristics of Cardiac Muscles

Specialized Characteristics of Cardiac Muscles

The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

EdTech Cache: A database of interactive learning content for dental education and beyond.

Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD·2026

Same author

Metaverse in dental hygiene education: Are we prepared for the future?

Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD·2026

Same author

<i>Save Our School</i>: an educational game made with Gimkit Creative.

Canadian medical education journal·2026

Same author

Alternative organelle targeting of OPA1 mediates fatty acid release from lipid droplets.

bioRxiv : the preprint server for biology·2026

Same author

Featuring the application of biochemistry in dental practice through a self-directed assignment: A descriptive study.

PloS one·2026

Same author

Quiz Game Show With PowerPoint and Zoom: Revitalizing a Classical Tool for Modern Learners.

Journal of dental education·2026

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Measuring Fast Calcium Fluxes in Cardiomyocytes

Measuring Fast Calcium Fluxes in Cardiomyocytes

Published on: November 29, 2011

Caveolin-1 exists and may function in cardiomyocytes.

Woo Jung Cho¹, Ava K Chow, Richard Schulz

¹Department of Pharmacology, Medical Sciences Building, University of Alberta, Edmonton, AB T6G2H7, Canada.

Canadian Journal of Physiology and Pharmacology

|February 5, 2010

Summary

This summary is machine-generated.

Caveolin-1 is present in mouse ventricular cardiac myocytes, not just endothelial cells. This finding clarifies the protein

More Related Videos

Primary Culture of Adult Rat Heart Myocytes

Primary Culture of Adult Rat Heart Myocytes

Published on: June 16, 2009

Related Experiment Videos

Last Updated: Jun 16, 2026

Measuring Fast Calcium Fluxes in Cardiomyocytes

Measuring Fast Calcium Fluxes in Cardiomyocytes

Published on: November 29, 2011

Primary Culture of Adult Rat Heart Myocytes

Primary Culture of Adult Rat Heart Myocytes

Published on: June 16, 2009

Area of Science:

Cardiovascular Biology
Cellular Biology
Molecular Cardiology

Background:

The presence of caveolin-1 in mouse ventricular cardiac myocytes is debated, with some studies suggesting it is exclusive to endothelial cells.
Recent research indicates matrix metalloproteinase-2 (MMP-2) colocalizes with caveolin-1 in cardiac myocytes, and its absence affects myocyte function.

Purpose of the Study:

To definitively determine the presence of caveolin-1 in mouse ventricular cardiac myocytes.
To differentiate caveolin-1 localization in cardiac myocytes versus endothelial cells.

Main Methods:

Immunolabeling of mouse cardiac tissue.
Utilizing antibodies for caveolin-1 and caveolin-2, with caveolin-2 known to be endothelial cell-specific.
Comparative analysis of labeling patterns in cardiac myocytes and endothelial cells.

Main Results:

Mouse ventricular cardiac myocytes showed positive labeling for caveolin-1, independent of caveolin-2.
Endothelial cells exhibited labeling for both caveolin-1 and caveolin-2.
This confirms caveolin-1 expression in both cardiac myocytes and endothelial cells.

Conclusions:

Caveolin-1 is indeed present in mouse ventricular cardiac myocytes.
This validates previous findings on the functional impact of caveolin-1 loss in cardiac myocytes, potentially involving MMP-2.