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Updated: Jun 16, 2026
04:41
Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
Genetics of keloid scarring
1Plastic and Reconstructive Surgery Research, Epithelial Sciences, School of Translational Medicine, The Manchester Interdisciplinary Biocentre (MIB), University of Manchester, 131 Princess Street, Manchester M17ND, UK.
Archives of Dermatological Research
|February 5, 2010
Summary
Genetic factors influence keloid disease (KD), a raised skin scar. Research suggests varied inheritance patterns and specific gene pathways involved in KD development, offering potential for new treatments.
Area of Science:
- Dermatology
- Genetics
- Molecular Biology
Background:
- Keloid disease (KD) is a raised fibroproliferative scar following skin trauma.
- The exact cause and management of KD remain unclear.
- Genetic susceptibility, including familial heritability and ethnic prevalence, is strongly suggested.
Purpose of the Study:
- To review and synthesize current literature on the genetic aspects of keloid disease.
- To identify inheritance patterns, linkage loci, and associated genes in KD.
- To explore gene pathways implicated in KD pathogenesis.
Main Methods:
- Comprehensive literature search using Scopus, Scirus, and PubMed for genetic aspects of KD.
- Analysis of inheritance patterns, linkage studies, and case-control association studies.
- Detailed comparison of genes from seven whole genome gene expression microarray studies.
Main Results:
- Predominantly autosomal dominant inheritance pattern observed in KD.
- Identified linkage loci on chromosomes 2q23 and 7p11.
- Reported significant human leukocyte antigen (HLA) alleles and at least 25 dysregulated genes in KD patients.
Conclusions:
- Multiple genes likely contribute to keloid disease susceptibility.
- Understanding KD genetics may improve diagnostic, therapeutic, and prognostic strategies.
- Key pathways involved include apoptosis, MAPK, TGF-β, IL-6, and PAI-1.
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