Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A case-control study examining the relationship between social cognition and post-traumatic stress disorder.

BJPsych open·2026
Same author

Corrigendum to "Fornix subdivisions and spatial learning: a diffusion MRI study" [Neuropsychologia 222, 15 February 2026, 109350].

Neuropsychologia·2026
Same author

Fornix subdivisions and spatial learning: a diffusion MRI study.

Neuropsychologia·2025
Same author

Correction: WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis.

Scientific data·2025
Same author

Multimodal MEG and Microstructure-MRI Investigations of the Human Hippocampal Scene Network.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis.

Scientific data·2025

Related Experiment Video

Updated: Jun 16, 2026

Assessing Burrowing, Nest Construction, and Hoarding in Mice
08:23

Assessing Burrowing, Nest Construction, and Hoarding in Mice

Published on: January 5, 2012

Excessive hoarding in Parkinson's disease.

Sean S O'Sullivan1, Atbin Djamshidian, Andrew H Evans

  • 1Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom. sosulliv@ion.ucl.ac.uk

Movement Disorders : Official Journal of the Movement Disorder Society
|February 5, 2010
PubMed
Summary

Hoarding is more common in Parkinson's disease (PD) patients with impulsive-compulsive behaviors (ICBs). These findings suggest hoarding in PD is linked to impulsive behaviors and poor self-control.

More Related Videos

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
09:27

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Published on: January 5, 2016

Related Experiment Videos

Last Updated: Jun 16, 2026

Assessing Burrowing, Nest Construction, and Hoarding in Mice
08:23

Assessing Burrowing, Nest Construction, and Hoarding in Mice

Published on: January 5, 2012

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
09:27

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Published on: January 5, 2016

Area of Science:

  • Neuroscience
  • Psychiatry
  • Movement Disorders

Background:

  • Hoarding is a psychiatric condition not previously studied in Parkinson's disease (PD).
  • Impulsive-compulsive behaviors (ICBs) are known to affect PD patients.
  • Understanding hoarding in PD is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate hoarding tendencies in Parkinson's disease patients.
  • To assess the association between hoarding and impulsive-compulsive spectrum behaviors (ICBs) in PD.
  • To compare hoarding prevalence and related factors in PD patients with and without ICBs, and healthy controls.

Main Methods:

  • Comparative study design involving three groups: PD with ICBs (n=39), PD without ICBs (n=61), and healthy controls (n=50).
  • Assessment of hoarding, impulse buying, self-control, obsessive-compulsive symptoms, depression, and anxiety.
  • Multivariate regression analyses to identify independent predictors of hoarding in PD.

Main Results:

  • Hoarding was significantly more prevalent in PD patients with ICBs (27.8%) compared to those without ICBs (3.5%) (P = 0.001).
  • Hoarding correlated positively with impulsive buying, obsessive-compulsive symptoms, and PD duration; it negatively correlated with self-control.
  • Impulsive buying and the presence of ICBs were independently associated with hoarding in PD.

Conclusions:

  • Hoarding is a relevant issue in Parkinson's disease, particularly in patients with ICBs.
  • Excessive hoarding in PD appears to be part of the spectrum of impulsive behaviors.
  • Findings highlight the need to consider hoarding and impulse control in the management of PD patients with ICBs.