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Updated: Jun 5, 2026

Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes
Published on: December 15, 2023
A case-control study examining the relationship between social cognition and post-traumatic stress disorder
Chantelle E Wiseman1, Andrew D Lawrence2,3, Jonathan I Bisson4
1Department of Population Health Sciences, https://ror.org/0524sp257University of Bristol, UK.
Difficulties in mentalising, the ability to understand others' mental states, are linked to trauma and post-traumatic stress disorder (PTSD). These social cognition impairments may be crucial for predicting PTSD risk and aiding recovery.
Area of Science:
- Psychology
- Neuroscience
- Mental Health Research
Background:
- Social cognition, especially mentalising, is hypothesized to influence trauma and PTSD risk and recovery.
- A comprehensive understanding of social cognitive deficits in PTSD is lacking.
Purpose of the Study:
- To investigate the association between variations in social cognition and the presence of trauma and PTSD.
- To explore the role of mentalising in the context of trauma exposure and PTSD symptoms.
Main Methods:
- Recruited 98 participants with PTSD symptoms and 99 controls.
- Administered a battery of social cognition tasks (emotion recognition, social attribution, mentalisation) and measures of trauma, PTSD, and verbal IQ.
- Employed logistic regression analyses, adjusted for covariates, to examine relationships.
Main Results:
- Hypomentalisation correlated with trauma exposure and increased odds of PTSD symptoms.
- Hypermentalising (indicated by increased use of mentalising language) was also associated with higher odds of PTSD symptoms.
- Findings suggest a significant link between mentalising abilities and PTSD severity.
Conclusions:
- Mentalising difficulties are associated with PTSD symptoms.
- Mentalising capacity may serve as a potential biomarker for predicting PTSD risk.
- Further research into mentalising could inform PTSD prevention and intervention strategies.
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