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Updated: Jun 16, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
[Expression of cytokeratins in tumors with perineural differentiation]
Abstract:
Twenty tumors with perineural differentiation (1 intraneural perineurioma, 10 conventional soft tissue perineuriomas, 3 reticular, 3 sclerosing, 1, atypical, and 2 malignant ones) were studied using a panel of antibodies directed against epithelial antigens. Seven (35%) cases were stained for CK14, 3 (15%) for AE1/AE3, and 2 (10%) for CAMS.2. These tumors showed focal expression of cytokeratins with labeling only a portion of cytoplasm. All tumors were negative for CEA, CK5/6, CK7, CK8, CK10, CK13, CK18, CK19, and CK20. The results of this investigation may be useful in the differential diagnosis of perineural tumors.

