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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Related Experiment Video

Updated: Jun 16, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Update in vitamin D.

John S Adams1, Martin Hewison

  • 1UCLA-Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095-7358, USA. jsadams@mednet.ucla.edu

The Journal of Clinical Endocrinology and Metabolism
|February 6, 2010
PubMed
Summary
This summary is machine-generated.

Vitamin D insufficiency is rapidly increasing in the US, affecting over 90% of minority populations and nearly 75% of white individuals. This review explores causes, health impacts, and supplementation strategies for vitamin D deficiency.

Related Experiment Videos

Last Updated: Jun 16, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

  • Nutritional Science
  • Public Health
  • Endocrinology

Background:

  • Recent data indicate a significant rise in vitamin D insufficiency across the United States.
  • National Health and Nutrition Examination Survey (NHANES) data highlight increasing prevalence, particularly among minority populations.
  • Vitamin D insufficiency affects over 90% of Black, Hispanic, and Asian populations and nearly 75% of the white population.

Purpose of the Study:

  • To investigate the reasons behind the escalating decline in vitamin D status in the US.
  • To examine the detrimental effects of vitamin D insufficiency on skeletal, infectious, inflammatory, and metabolic health.
  • To outline therapeutic strategies and effective methods for vitamin D supplementation.

Main Methods:

  • Review of recent epidemiological data, particularly from NHANES.
  • Analysis of existing literature on the health impacts of vitamin D deficiency.
  • Synthesis of evidence regarding vitamin D supplementation efficacy and rationale.

Main Results:

  • Vitamin D insufficiency prevalence has nearly doubled in the past decade.
  • Significant portions of all racial and ethnic groups in the US are vitamin D insufficient.
  • The review synthesizes causes, health consequences, and solutions for widespread vitamin D deficiency.

Conclusions:

  • Urgent attention is needed to address the growing vitamin D insufficiency crisis in the US.
  • Understanding the multifaceted health impacts is crucial for public health interventions.
  • Effective dietary supplementation strategies are vital for improving population vitamin D status.