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Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
Published on: December 23, 2022
A brief overview of Escherichia coli O157:H7 and its plasmid O157
Ji Youn Lim1, Jangwon Yoon, Carolyn J Hovde
1Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID 83844, USA.
Abstract:
Enterohemorrhagic Escherichia coli O157:H7 is a major food-borne pathogen causing severe disease in humans worldwide. Healthy cattle are a reservoir of E. coli O157:H7 and bovine food products and fresh produce contaminated with bovine waste are the most common sources for disease outbreaks in the United States. E. coli O157:H7 also survives well in the environment. The ability to cause human disease, colonize the bovine gastrointestinal tract, and survive in the environment, requires that E. coli O157:H7 adapt to a wide variety of conditions. Three major virulence factors of E. coli O157:H7 have been identified including Shiga toxins, a pathogenicity island called the locus of enterocyte effacement, and an F-like plasmid, pO157. Among these virulence factors, the role of the pO157 is least understood. This review provides a board overview of E. coli O157:H7 with an emphasis on the pO157.
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