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Updated: Jun 16, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics
Richard C Becker1, Thomas Povsic, Mauricio G Cohen
1Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina 27715, USA. Becke021@mc.duke.edu
Abstract:
Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.
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