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Updated: Jun 16, 2026
09:51
Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS
Published on: April 13, 2016
Metalloproteases and the degradome
Alejandro P Ugalde1, Gonzalo R Ordóñez, Pedro M Quirós
1Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, Oviedo, Spain.
Methods in Molecular Biology (Clifton, N.J.)
|February 6, 2010
Summary
Metalloproteases are crucial enzymes using metal ions for hydrolysis, vital in many biological processes. This chapter details their complexity, roles in health and disease, and specific families like ADAMs, ADAMTSs, and MMPs.
Area of Science:
- Biochemistry and Molecular Biology
- Enzymology
Background:
- Metalloproteases are a diverse class of enzymes utilizing metal ions for catalytic activity.
- They are essential for numerous biological functions across various organisms.
- Their study is critical for understanding cellular processes and disease mechanisms.
Purpose of the Study:
- To provide a comprehensive overview of metalloproteases within the context of the degradome.
- To elucidate the functional significance of metalloproteases in biological and pathological conditions.
- To analyze key metalloprotease families: ADAMs, ADAMTSs, and MMPs.
Main Methods:
- Review of existing literature on metalloprotease structure, function, and classification.
- Analysis of the degradome as a framework for understanding protease gene sets.
- Detailed examination of specific metalloprotease families and their associated pathologies.
Main Results:
- Metalloproteases are a highly populated catalytic class with diverse roles.
- Their functional relevance spans normal physiology and various pathological states.
- ADAMs, ADAMTSs, and MMPs are highlighted for their increasing importance in human diseases.
Conclusions:
- Metalloproteases are fundamental enzymes with broad biological impact.
- Understanding their complexity and roles is key to addressing diseases like cancer and arthritis.
- Further research into ADAMs, ADAMTSs, and MMPs holds therapeutic potential.
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