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Formulation and Characterization of Bioactive Agent Containing Nanodisks
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Characterization and formulation optimization of solid lipid nanoparticles in vitamin K1 delivery
Chi-Hsien Liu1, Chao-Ting Wu, Jia-You Fang
1Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, ROC. chl@mail.cgu.edu.tw
Drug Development and Industrial Pharmacy
|February 9, 2010
Summary
Solid lipid nanoparticles (SLNs) effectively encapsulate vitamin K1, showing high entrapment efficiency and stability for oral delivery. These SLNs offer a promising carrier for vitamin K1 (phylloquinone) supplementation.
Area of Science:
- Nanotechnology
- Pharmaceutics
- Biochemistry
Background:
- Solid lipid nanoparticle (SLN) systems are versatile drug delivery platforms.
- Vitamin K1 (phylloquinone) is crucial for hemostasis and hemorrhage prevention.
Purpose of the Study:
- To develop and optimize vitamin K1-loaded SLNs for potential oral delivery.
- To evaluate the stability and characteristics of vitamin K1-loaded SLNs.
Main Methods:
- Optimization of triglycerides and surfactants (Myverol, Pluronic) using central composite design and response surface methodology.
- Characterization of SLNs using photon correlation spectroscopy, differential scanning calorimetry, and transmission electron microscopy.
- Evaluation of ultrasonication duration and drug load effects on particle size and entrapment efficiency.
Main Results:
- Vitamin K1-loaded SLNs achieved a mean size of 125 nm and zeta potential of -23 mV.
- SLNs exhibited an imperfect crystalline lattice and spherical morphology.
- High entrapment efficiency (>85%) was observed for vitamin K1 payloads <5%.
Conclusions:
- Vitamin K1-loaded SLNs demonstrated excellent stability in simulated gastric and intestinal fluids for 54 hours.
- The prepared SLNs maintained particle size and vitamin K1 entrapment after 4 months of storage.
- These SLNs show potential as effective oral carriers for vitamin K1 delivery.
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