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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
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Inflammation versus adaptive immunity in cancer pathogenesis.

Sheraz Yaqub1, Einar Martin Aandahl

  • 1The Biotechnology Centre of Oslo and Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, Oslo, Norway.

Critical Reviews in Oncogenesis
|February 9, 2010
PubMed
Summary

The immune system

Area of Science:

  • Immunology
  • Oncology
  • Cancer Biology

Background:

  • Cancer pathogenesis involves complex interactions between tumor cells, stroma, and the immune system.
  • Immune system components can both inhibit and promote cancer development, including tumor initiation, growth, invasivity, and metastasis.
  • Inflammatory conditions create a pro-cancer microenvironment, while tumors can exacerbate inflammation.

Purpose of the Study:

  • To review emerging concepts in cancer pathogenesis.
  • To highlight the role of inflammatory and adaptive immune components in tumor-stromal interactions.

Main Methods:

  • Literature review of emerging concepts in cancer pathogenesis.
  • Analysis of interactions between immune system components, tumor cells, and stromal tissue.

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Published on: March 7, 2025

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Main Results:

  • An intact immune system is linked to a favorable prognosis in cancer.
  • The inflammatory response and adaptive immune system share cellular and humoral features.
  • Emerging evidence points to significant roles for inflammatory and adaptive immunity in cancer pathogenesis.

Conclusions:

  • The interplay between the immune system, tumor, and stroma is crucial in cancer development.
  • Understanding these complex interactions is key to developing novel cancer therapies.
  • Inflammatory and adaptive immune responses are critical factors in cancer pathogenesis and progression.