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Related Concept Videos

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
What is the Immune System?01:38

What is the Immune System?

Overview
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...

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Updated: Jun 16, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

Vitamin D and innate immunity.

Jeremiah Miller1, Richard L Gallo

  • 1Department of Medicine, University of California, San Diego, USA.

Dermatologic Therapy
|February 9, 2010
PubMed
Summary

Vitamin D impacts the immune system, affecting skin conditions like atopic dermatitis and psoriasis. More research is needed to establish safe and effective vitamin D supplementation guidelines.

Area of Science:

  • Immunology
  • Dermatology
  • Endocrinology

Background:

  • Vitamin D is crucial for bone health.
  • Emerging research highlights vitamin D's roles in immune function, cardiovascular health, and cancer prevention.
  • The immune effects of vitamin D are particularly relevant to dermatological conditions such as atopic dermatitis, psoriasis, and skin cancer.

Purpose of the Study:

  • To review the current understanding of vitamin D's role in the immune system.
  • To discuss the safety and optimal dosage of vitamin D from various sources.
  • To identify risk factors for vitamin D deficiency and the need for supplementation.

Main Methods:

  • Literature review of existing studies on vitamin D and the immune system.
  • Analysis of data regarding vitamin D sources, safety, and efficacy.

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  • Examination of risk factors associated with vitamin D deficiency.

    • Main Results:

    • Vitamin D significantly influences immune responses, with implications for inflammatory skin diseases.
    • There is considerable debate regarding the appropriate and safe dosage of vitamin D.
    • Various factors contribute to vitamin D deficiency, necessitating careful consideration for supplementation.

    Conclusions:

    • Vitamin D plays a critical role in immune regulation, impacting dermatological health.
    • Establishing clear, evidence-based guidelines for vitamin D supplementation is essential.
    • Further controlled clinical trials are required to solidify recommendations for vitamin D therapy.