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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Indoleamine 2,3-dioxygenase in tumor induced tolerance

Xiao-Qian Liu1, Xin Wang

  • 1Department of Hematology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.

Chinese Medical Journal
|February 9, 2010
PubMed
Summary

Indoleamine 2,3-dioxygenase (IDO) is upregulated in tumors, contributing to tumor-induced tolerance. A feedback system between IDO and regulatory T cells plays a key role in this acquired tolerance mechanism.

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