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Oxidative stress and peripheral skeletal muscle dysfunction in rats with emphysema
Xiao-lei Zhang1, Bao-sen Pang, Xiao-li Hou
1Department of Respiratory Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Chinese Medical Journal
|February 9, 2010
Summary
Oxidative stress in emphysema (EMP) rats increased muscle lipofuscin and antioxidant enzyme activity. This local oxidative stress impaired gastrocnemius muscle fatigue endurance, highlighting its functional consequences.
Area of Science:
- Respiratory Medicine
- Skeletal Muscle Physiology
- Oxidative Stress Research
Background:
- Peripheral skeletal muscle dysfunction is common in chronic obstructive pulmonary disease (COPD).
- The underlying mechanisms are unclear, but oxidative stress is a potential contributor.
- This study investigates the link between local oxidative stress and muscle performance in an emphysema model.
Purpose of the Study:
- To determine if local oxidative stress is associated with reduced peripheral skeletal muscle performance in rats with emphysema.
- To examine the impact of emphysema on gastrocnemius muscle mechanical properties and oxidative stress markers.
Main Methods:
- Mechanical properties of gastrocnemius muscle were measured in Sprague-Dawley rats with elastase-induced emphysema (EMP) and control (CON) groups.
- Lipofuscin inclusions, myocyte apoptosis, and antioxidant enzyme activities were assessed in muscle tissue.
- In situ mechanical testing evaluated muscle force and fatigue endurance.
Main Results:
- Emphysema rats (EMP) showed significantly higher lipofuscin inclusions and increased antioxidant enzyme activity in gastrocnemius muscle compared to controls (CON).
- EMP muscle exhibited reduced fatigue endurance but no significant change in maximal tetanic force.
- A positive correlation was observed between lipofuscin levels and reduced muscle fatigue recovery time in EMP rats.
Conclusions:
- Local oxidative stress in the gastrocnemius muscle of emphysema rats is associated with impaired muscle function.
- Oxidative stress, indicated by lipofuscin accumulation, may play a significant role in peripheral skeletal muscle dysfunction in emphysema.
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