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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Updated: Jun 16, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Punctate porokeratotic keratoderma.

Ali Alikhan1, Tracy Burns, Omid Zargari

  • 1MacNeal Hospital, Berwyn, Illinois, USA. alialikhan1@yahoo.com

Dermatology Online Journal
|February 9, 2010
PubMed
Summary
This summary is machine-generated.

This study details a case of punctate porokeratotic keratoderma (PPK), a rare skin condition. Histopathology confirmed the diagnosis, highlighting key features of this disorder.

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Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Punctate porokeratotic keratoderma (PPK) is a rare genodermatosis.
  • It presents as small, keratotic papules on the hands and feet.

Purpose of the Study:

  • To report a case of PPK in a young woman.
  • To discuss the clinical and histopathological features of PPK.
  • To review the differential diagnosis and treatment options for PPK.

Main Methods:

  • Clinical examination of skin lesions.
  • Histopathological analysis of skin biopsy.
  • Literature review for disease characteristics.

Main Results:

  • A 29-year-old woman presented with multiple small keratotic papules on her fingers and toes.
  • Histopathology showed a compact parakeratotic column and a poorly developed stratum granulosum.
  • These findings are characteristic of punctate porokeratotic keratoderma.

Conclusions:

  • The case highlights the typical presentation and histopathological findings of PPK.
  • Understanding these features is crucial for accurate diagnosis.
  • Further research into etiology and treatment is warranted.