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Psoriasis and Alopecia: Unveiling the Links.
Mohammad Reza Pourani1, Yasaman Khajeamiri2, Fahimeh Abdollahimajd3,4,5
1Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dermatology Practical & Conceptual
|November 14, 2025
Summary
Psoriasis can cause hair loss through various mechanisms, including telogen effluvium and drug side effects. Patients with psoriasis have an increased risk of developing alopecia areata, emphasizing the need for further research.
Area of Science:
- Dermatology
- Immunology
- Pathophysiology
Background:
- Psoriasis is a chronic inflammatory skin condition affecting quality of life.
- Scalp involvement is common, and alopecia is a complex issue in psoriasis patients.
- Limited research exists on the multifaceted nature of alopecia in psoriasis.
Purpose of the Study:
- To review and investigate diverse alopecia types in psoriasis.
- To explore potential underlying mechanisms of hair loss in psoriasis.
Main Methods:
- Comprehensive literature review conducted.
- Focused on psoriasis connections with alopecia areata (AA), drug-induced alopecia, and psoriatic alopecia.
Main Results:
- Psoriasis and alopecia share common pathways.
- Psoriatic alopecia is typically non-scarring telogen effluvium, often reversible.
- Drug-induced alopecia can occur with systemic treatments and biologics (e.g., TNF-α inhibitors, IL-17 blockers).
- Psoriasis patients exhibit a higher risk for alopecia areata, suggesting shared autoimmune mechanisms.
Conclusions:
- Understanding alopecia types and causes in psoriasis is vital for effective management.
- Further research is necessary to fully elucidate the relationship between psoriasis and alopecia.
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