Related Experiment Video
Updated: Jun 16, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Phosphorylated c-Jun NH2-terminal kinase is overexpressed in human papillary thyroid carcinomas and associates with
Xiao Wang1, Lan Chao, Junhui Zhen
1Department of Surgery, Jinan Central Hospital, Shandong University School of Medicine, Jinan 250012, China. wangxiao@sdu.edu.cn
Abstract:
To evaluate the associations of phosphorylated c-Jun NH2-terminal kinase (p-JNK) expression with clinicopathological features in patients with papillary thyroid carcinoma, p-JNK expression were immunohistochemically measured in 121 thyroid samples. p-JNK was overexpressed in papillary thyroid carcinomas with respect to matched nontumorous tissues (P=0.000), which was supported by western blot analysis. Increased p-JNK expression was significantly associated with the presence of lymph node metastases (P=0.001) and advanced TNM stages (P=0.02). Furthermore, p-JNK expression was positively correlated with osteopontin (OPN) expression (r=0.58, P<0.001). Activation of p-JNK may play a role in the carcinogenesis and lymph node metastasis of papillary thyroid carcinoma, and may be a molecular target for therapeutic intervention.
Related Concept Videos
Hyperthyroidism II: Pathophysiology
MAPK Signaling Cascades
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
PI3K/mTOR/AKT Signaling Pathway
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...