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Updated: Jun 16, 2026

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
Published on: June 16, 2018
Integrin signaling and lung cancer
Francesca Caccavari1, Donatella Valdembri, Chiara Sandri
1Laboratory of Cell Signaling, Division of Vascular Biology, Institute for Cancer Research and Treatment and Department of Oncological Sciences, University of Torino School of Medicine, Candiolo (TO), Italy.
Abstract:
The poor prognosis of most non small cell lung carcinomas is due to their ability to efficiently invade surrounding tissues and blood vessels, finally metastasizing to distant organs. Integrin mediated adhesive interaction with the surrounding extracellular matrix is a key limiting step in the regulation of the invasive properties of several cancer cell types. Here, we examine the rising evidences about the role that integrins can play in the physiopathology of non small cell lung carcinomas by regulating cell adhesion as well as the activation of growth factors and the traffic of their cognate receptors. Modulation of the signaling pathways controlled by integrins in lung cancer cells might offer the opportunity to design and develop new drugs that might be successfully combined with conventional chemotherapy and radiotherapy.
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