Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Gateways to clinical trials.

A Tomillero, M A Moral

Methods and Findings in Experimental and Clinical Pharmacology

|February 9, 2010

Summary

This summary is machine-generated.

This study details a comprehensive list of novel therapeutic agents, including targeted therapies and biologics, for various diseases. These advancements represent significant progress in drug development and treatment options.

Related Concept Videos

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

Drug Administration and Therapy Phases: Overview

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...

Bioequivalence studies: Biowaivers

Bioequivalence studies: Biowaivers

In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2011

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2011

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2010

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2010

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2010

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2010

Same journal

[Proceedings of the XVIII TASPE Seminar, Granada, Spain, 4-5 February 2010].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Treatment algorithm for gastrointestinal graft-versus-host disease].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Treatment of chronic graft-versus-host disease with protein tyrosine kinase inhibitors].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Classification of chronic graft-versus-host disease].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Pegfilgrastim in hematopoietic stem cell transplantation].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Allogeneic transplantation in multiple myeloma patients: results and recommendations in February 2010].

Methods and findings in experimental and clinical pharmacology·2011

See all related articles

Area of Science:

Pharmacology and Therapeutics
Drug Discovery and Development
Biotechnology

Context:

The landscape of pharmaceutical research is rapidly evolving.
Numerous novel therapeutic agents are under investigation.
This includes small molecules, biologics, and targeted therapies.

Purpose:

To present a curated list of emerging therapeutic agents.
To highlight key compounds with potential clinical applications.
To serve as a reference for researchers and clinicians.

Summary:

The abstract lists a wide array of investigational drugs, encompassing small molecules like Imatinib mesylate and biologics such as Trastuzumab.
It includes targeted therapies like Gefitinib and immunotherapies like Ipilimumab.

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Related Experiment Videos

Last Updated: Jun 16, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

The list also features agents for diverse conditions, from cancer to cardiovascular diseases.

Impact:

Facilitates an understanding of the current pipeline of novel therapeutics.
Aids in identifying potential treatments for unmet medical needs.
Supports strategic decision-making in pharmaceutical research and development.