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Published on: January 21, 2020
Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis
Neetha Shetty1, Biju Thomas, Amita Ramesh
1Assistant Professor, Department of Periodontics, MCODS, Mangalore, India.
Background:
Diabetes mellitus is a systemic condition that has long been associated with an increased risk and severity of periodontal disease. Polymorphonuclear leukocytes (PMNs) play a key role in the maintenance of gingival and periodontal health. Reduced PMN function has been found in patients with diabetes.
Aim:
The objective of this study was to evaluate PMN functions in 15 diabetic patients with chronic generalized periodontitis.
Materials And Methods:
Chemotaxis, superoxide production, phagocytosis and killing of Porphyromonas gingivalis by diabetic PMNs were evaluated relative to healthy and matched controls.
Results:
These analyses revealed a significant (P < 0.01) depression in the number of diabetic PMNs migrating along an fMLP gradient. In addition, a significant (P < 0.01) enhancement of diabetic PMN superoxide production was observed. Phagocytosis (P < 0.05) and killing by diabetic PMN of P. gingivalis was also impaired significantly (P < 0.01).
