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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 16, 2026

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models
08:43

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models

Published on: September 18, 2018

Modeling prostate cancer: a perspective on transgenic mouse models.

Varinder Jeet1, Pamela J Russell, Aparajita Khatri

  • 1Oncology Research Centre, Prince of Wales Hospital, Barker St., Randwick, NSW, 2031, Australia.

Cancer Metastasis Reviews
|February 10, 2010
PubMed
Summary

Transgenic mouse models are crucial for understanding prostate cancer (PC) progression and developing new therapies. These models, particularly those with multiple genetic alterations, offer insights into PC

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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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An Orthotopic Murine Model of Human Prostate Cancer Metastasis

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Related Experiment Videos

Last Updated: Jun 16, 2026

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models
08:43

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models

Published on: September 18, 2018

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Area of Science:

  • Oncology
  • Genetics
  • Animal Models

Background:

  • Prostate cancer (PC) treatment is effective for early stages but challenging for advanced, heterogeneous disease.
  • Understanding PC genesis and progression is vital for developing novel targeted therapies.

Purpose of the Study:

  • To review the development and utility of transgenic mouse models in prostate cancer (PC) research.
  • To highlight how these models aid in understanding PC molecular and pathological aspects.

Main Methods:

  • Development of transgenic mouse models through modulation of key cancer-related genes (oncogenes, receptors, regulators, tumor suppressors).
  • Utilizing conditional knockout technologies for advanced genetic alterations.
  • Focusing on immunocompetent models for in-vivo studies.

Main Results:

  • Transgenic models have significantly advanced the understanding of PC initiation and progression.
  • Models with multiple genetic alterations better recapitulate PC complexity.
  • New generation transgenics enhance knowledge of PC tumorigenesis and therapeutic evaluation.

Conclusions:

  • Transgenic mouse models are indispensable tools for prostate cancer (PC) research.
  • These models are critical for evaluating the efficacy of new targeted therapies.
  • Advances in genetic engineering continue to expand their utility in PC studies.