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Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Panic Disorder01:27

Panic Disorder

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...

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Articles linked to this work by shared authors, journal, and citation graph.

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[Fibromyalgia: beyond the depression].

Revista de enfermeria (Barcelona, Spain)·2010
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A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

[Co-morbility during depression].

Ma Pilar Montesó Curto1, Ma Violante Martínez Quintana

  • 1UNED, Departamento Enfermería, Universidad Rovira i Virgili. pmonteso.ics@gencat.cat

Revista De Enfermeria (Barcelona, Spain)
|February 11, 2010
PubMed
Summary

Depression can manifest from organic diseases or cause them, impacting physical health. The brain, endocrine, and immune systems form a complex network influencing this bidirectional relationship.

Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Context:

  • Growing research explores the brain's influence on bodily diseases, moving beyond studying disease effects on the brain.
  • Epidemiological studies reveal bidirectional relationships between depression and various chronic and acute illnesses.

Purpose:

  • To review the complex interplay between the central nervous system, endocrine system, and immunological system in the context of depression and disease.
  • To highlight the bidirectional nature of depression-disease onset and the role of inflammation and cytokines.

Summary:

  • Depression's link to physical health is multifaceted, involving bidirectional pathways between mental and physical well-being.
  • The central nervous system, endocrine system, and immune system communicate bidirectionally, influencing cytokine balance and disease development.

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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

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Last Updated: Jun 16, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
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A New Method for Inducing a Depression-Like Behavior in Rats

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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

  • Conditions like chronic pain, fatigue, and neurodegenerative disorders are frequently associated with depression, indicating a complex psychosomatic connection.

    • Impact:

    • Understanding this complex network is crucial for developing integrated treatment approaches for patients with depression and comorbid physical conditions.
    • This research underscores the importance of considering mental health as a critical factor in managing and preventing physical diseases.