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Updated: Jun 16, 2026

Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
Alpha-mannosidase activity in synovial fluid
1Dept. of Internal Medicine, Section of Rheumatic Diseases, University of Colorado Medical Center, Denver, Colorado, USA.
Abstract:
A microassay technique for the evaluation of synovial fluid alpha-mannosidase activity is presented with the evaluation of 184 synovial fluid samples from a variety of arthropathic conditions. The results indicate a close correlation of enzyme activity with synovial fluid cell count and the degree of inflammation associated with the various types of joint disease. It is suggested that the evaluation of this and other lysosomal glycosidases offer a quantitative method for the evaluation of inflammatory joint disease.
