Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Published on: March 9, 2022

An evaluation of "I, Pancreas" algorithm performance in silico.

Malgorzata E Wilinska¹, Marianna Nodale

¹University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom. mew37@medschl.cam.ac.uk

Journal of Diabetes Science and Technology

|February 11, 2010

Summary

The "I, Pancreas" algorithm safely controlled glucose in critically ill virtual patients, achieving tight glycemic control 38% of the time during a 48-hour simulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cambridge hybrid closed-loop use in very young children with type 1 diabetes: Parental expectancies during long-term home use.

Diabetic medicine : a journal of the British Diabetic Association·2026

Same author

Insulin Bolus Patterns in Newly Diagnosed Youth With Type 1 Diabetes Using a Hybrid Closed-Loop Insulin Delivery System.

Journal of diabetes science and technology·2026

Same author

Lived experience of fully closed-loop insulin delivery in adolescents with type 1 diabetes and HbA1c above target.

Diabetes research and clinical practice·2026

Same author

Real-World Clinical Impact of Using Personal Glucose Targets in a Hybrid Closed-Loop System Differs According to Age.

Diabetes technology & therapeutics·2025

Same author

Trends in Total Daily Dose and Variability of Insulin Requirements in Newly Diagnosed Children and Adolescents with Type 1 Diabetes over 48 Months.

Diabetes technology & therapeutics·2025

Same author

Fully Closed-Loop Improves Glycemic Control Compared with Pump with CGM in Adolescents with Type 1 Diabetes and HbA1c Above Target: A Two-Center, Randomized Crossover Study.

Diabetes technology & therapeutics·2025

Area of Science:

Critical Care Medicine
Diabetes Technology
Computational Biology

Background:

Achieving tight glycemic control in critically ill patients is challenging.
New insulin titrating algorithms are needed to improve glucose management.
The
algorithm is a novel approach for insulin titration.

Purpose of the Study:

To evaluate the performance of the proposed "I, Pancreas" insulin titrating algorithm.
To assess the algorithm's ability to achieve tight glycemic control in a simulated critically ill population.
To determine the safety and efficacy of the algorithm in silico.

Main Methods:

A simulation environment with 10 critically ill virtual subjects was utilized.
The "I, Pancreas" algorithm was implemented in MATLAB.

More Related Videos

Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window

Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window

Published on: May 6, 2021

Computer-assisted Large-scale Visualization and Quantification of Pancreatic Islet Mass, Size Distribution and Architecture

Computer-assisted Large-scale Visualization and Quantification of Pancreatic Islet Mass, Size Distribution and Architecture

Published on: March 4, 2011

Related Experiment Videos

Last Updated: Jun 16, 2026

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Published on: March 9, 2022

Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window

Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window

Published on: May 6, 2021

Computer-assisted Large-scale Visualization and Quantification of Pancreatic Islet Mass, Size Distribution and Architecture

Computer-assisted Large-scale Visualization and Quantification of Pancreatic Islet Mass, Size Distribution and Architecture

Published on: March 4, 2011

Glucose control was simulated over a 48-hour period.

Main Results:

Mean blood glucose was maintained at 6.5 +/- 0.4 mmol/liter.
The algorithm achieved tight glycemic control 38% of the time (32-44%).
A single episode of mild hypoglycemia was observed over 480 hours of simulated control.

Conclusions:

The "I, Pancreas" algorithm demonstrated safe glucose control in a simulated critical care setting.
The algorithm showed potential for achieving tight glycemic control in critically ill patients.
Further in vivo studies are warranted to validate these in silico findings.