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Regulation of plasmacytoid dendritic cell development.
1Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. bvr2101@columbia.edu
Current Opinion in Immunology
|February 11, 2010
Summary
Plasmacytoid dendritic cells (PDC) are immune cells crucial for antiviral responses. Research shows they share developmental origins with other dendritic cells (DC) and that the E2-2 transcription factor influences their unique lymphoid characteristics.
Area of Science:
- Immunology
- Cell Biology
- Developmental Biology
Background:
- Plasmacytoid dendritic cells (PDC) are specialized immune cells known for rapid type I interferon secretion and direct virus recognition.
- The precise origin and lineage of PDCs have been debated due to their mixed lymphoid and dendritic cell (DC) features.
Purpose of the Study:
- To elucidate the cellular and molecular underpinnings of plasmacytoid dendritic cell (PDC) development.
- To clarify the lineage affiliation and developmental origins of PDCs.
Main Methods:
- Analysis of recent studies on cellular and molecular basis of PDC development.
- Investigation of genetic similarities between PDCs and classical antigen-presenting DCs.
- Examination of the role of E protein transcription factor E2-2 in PDC lineage commitment.
Main Results:
- Established common developmental origin and genetic similarity between PDCs and classical antigen-presenting DCs.
- Demonstrated that the E2-2 transcription factor controls PDC lineage commitment and gene expression.
Conclusions:
- PDC development is closely linked to other dendritic cell lineages.
- The transcription factor E2-2 plays a critical role in defining the unique 'lymphoid' characteristics of PDCs, consistent with its role in lymphocyte development.
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