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Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay

Gengrong Lin1, Lois M Ednie, Peter C Appelbaum

  • 1Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.

Antimicrobial Agents and Chemotherapy
|February 11, 2010
PubMed

Insights

ACHN-490 combined with daptomycin demonstrated synergy against most methicillin-resistant Staphylococcus aureus strains. This combination shows promise for treating resistant bacterial infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat due to its resistance to multiple antibiotics.
  • Novel therapeutic strategies are urgently needed to combat MRSA infections.
  • Understanding synergistic antibiotic combinations is crucial for developing effective treatments.

Purpose of the Study:

  • To evaluate the synergistic activity of ACHN-490 in combination with other antibiotics against MRSA.
  • To determine the efficacy of ACHN-490 and daptomycin, ceftobiprole, and linezolid combinations against diverse MRSA strains.

Main Methods:

  • Synergy time-kill studies were performed.
  • 47 MRSA strains with varying resistance phenotypes were tested.
  • Subinhibitory concentrations of ACHN-490 were combined with daptomycin, ceftobiprole, and linezolid.
  • Activity was assessed at 24 hours.

Main Results:

  • ACHN-490 plus daptomycin showed synergy against 43 out of 47 (91.5%) MRSA strains at 24 hours.
  • This combination was indifferent against 4 strains.
  • ACHN-490 and ceftobiprole demonstrated synergy in 17/47 strains.
  • ACHN-490 and linezolid combinations showed synergy in 6/47 strains.

Conclusions:

  • The combination of ACHN-490 and daptomycin exhibits potent synergistic activity against a high proportion of MRSA strains.
  • This combination represents a promising therapeutic option for treating MRSA infections.
  • Further investigation into ACHN-490 combinations is warranted.

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