Related Experiment Videos
The hemodynamic effects of Cremophor-EL
1Tampa General Hospital Transplantation Services, University of South Florida 33606.
Transplantation
|April 1, 1991
Summary
Parenteral cyclosporine can cause kidney damage. This study found that Cremophor-EL, a cyclosporine vehicle, significantly impacts cardiac output, blood pressure, and hepatic blood flow in dogs, suggesting a hemodynamic role in allograft dysfunction.
Area of Science:
- Pharmacology
- Cardiovascular Physiology
- Nephrology
Background:
- Parenteral cyclosporine is linked to increased renal toxicity.
- Cremophor-EL, the vehicle used, may cause histamine release and anaphylaxis.
Purpose of the Study:
- To investigate the hemodynamic effects of Cremophor-EL.
- To assess its impact on cardiac output, mean arterial pressure, and organ blood flow in canines.
Main Methods:
- Anesthetized canine model.
- Doppler flow probes to measure cardiac output and organ blood flow (hepatic, renal, pancreatic).
Main Results:
- Significant adverse effects observed on cardiac output, mean arterial pressure, and hepatic blood flow.
- Negative trends in renal and splenic blood flow did not reach statistical significance.
- Organ blood flow changes were partly independent of mean arterial pressure and Cremophor-EL dose.
Conclusions:
- Cremophor-EL can have profound adverse hemodynamic effects.
- Consider the hemodynamic role of Cremophor-EL in canine allograft dysfunction and renal toxicity.