A 7-year-old boy with acute onset of breathing difficulty
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Updated: Jun 16, 2026

Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
1Department of Pediatrics, Hospital Agramont, La Paz, Bolivia. ariel.a.salas@gmail.com
Insights
Group A Streptococcus (GAS) pharyngitis is common in children. A rare but fatal complication, streptococcal toxic shock syndrome, can occur even after treatment.
Area of Science:
- Microbiology
- Pediatrics
- Infectious Diseases
Background:
- Group A Streptococcus (GAS) is a significant global bacterial pathogen in children.
- GAS pharyngitis affects approximately 15% of school-aged children annually.
- Invasive GAS disease incidence is low (0.5%-2%) but rising.
Observation:
- This report details a case of a 7-year-old boy.
- The patient was treated for GAS pharyngitis.
- He subsequently developed fatal streptococcal toxic shock syndrome.
Findings:
- GAS pharyngitis can lead to severe, life-threatening invasive disease.
- Streptococcal toxic shock syndrome is a rare but devastating complication.
- This case highlights the potential severity of GAS infections.
Implications:
- Increased vigilance for invasive GAS disease is warranted, even post-treatment.
- Further research into GAS pathogenesis and prevention is crucial.
- This case underscores the importance of prompt recognition and management of GAS complications.
Abstract:
Group A streptococcus (GAS) is a major bacterial pathogen affecting children globally. Approximately 15% of school-age children experience a symptomatic episode of GAS culture-positive pharyngitis each year. Although the incidence of invasive GAS disease under these circumstances is low (0.5%-2%), an increasing number of invasive GAS cases have been reported over the last 2 decades. This report describes a 7-year-old boy who, after being treated for GAS pharyngitis, developed a fatal streptococcal toxic shock syndrome.
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