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Malignant renal tumors in tuberous sclerosis
1Department of Pediatric Urology, New York University Medical Center, New York.
Urology
|April 1, 1991
Summary
Renal carcinoma occurs bilaterally in 43% of patients with tuberous sclerosis by age 28. Histologic diagnosis can be challenging due to hamartomas and cystic changes.
Area of Science:
- Oncology
- Genetics
- Nephrology
Background:
- Tuberous sclerosis complex (TSC) is a genetic disorder.
- Renal involvement is common in TSC, with a risk of developing renal tumors.
- Von Hippel-Lindau syndrome is known for a higher frequency of renal cell carcinoma.