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Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Related Experiment Video

Updated: Jun 16, 2026

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.

Published on: September 18, 2014

Endocannabinoid control of gastric sensorimotor function in man.

K Ameloot¹, P Janssen, E Scarpellini

¹Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium.

Alimentary Pharmacology & Therapeutics

|February 12, 2010

Summary

The endocannabinoid system, specifically CB1 receptors, plays a role in regulating gastric accommodation in humans. Blocking these receptors with rimonabant significantly inhibited meal-induced gastric accommodation.

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In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments

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Published on: October 25, 2016

Area of Science:

Gastroenterology
Neurogastroenterology
Endocrinology

Background:

The physiological role of the endocannabinoid system in gastric motility and sensitivity remains largely unknown.
Dysfunction of the endocannabinoid system is implicated in food intake regulation and functional dyspepsia pathogenesis.

Purpose of the Study:

To investigate the effect of rimonabant, a cannabinoid 1 (CB1) receptor antagonist, on gastric sensorimotor function in healthy individuals.

Main Methods:

A placebo-controlled, double-blind, randomized crossover study was conducted with 12 healthy volunteers.
Participants received rimonabant (20 mg/day) or placebo for 4 days.
Gastric sensorimotor function was assessed using a gastric barostat and a liquid nutrient challenge test.

Main Results:

Rimonabant did not alter gastric compliance or sensitivity to distension.
The meal-induced gastric accommodation reflex was significantly inhibited by rimonabant (P = 0.02).
Maximal nutrient tolerance and meal-related symptoms were unaffected by rimonabant.

Conclusions:

Endocannabinoids acting via CB1 receptors are involved in controlling gastric accommodation in humans.
This suggests a potential therapeutic target for conditions involving altered gastric accommodation.