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Summary

This summary is machine-generated.

Long-term bisphosphonate therapy may lead to femur stress fractures in some patients. Early cessation of bisphosphonates is recommended for fractures, with preventive nailing considered for bilateral cases.

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Area of Science:

Orthopedics
Pharmacology
Radiology

Background:

Bisphosphonates are commonly prescribed for osteoporosis and other bone conditions.
Long-term use of bisphosphonates has been associated with various skeletal side effects.
A potential link between bisphosphonate therapy and femur stress fractures is under investigation.

Observation:

Three cases of bisphosphonate-associated femur stress fractures are presented.
Patients experienced prodromal leg pain or presented with spontaneous transverse subtrochanteric femur fractures.
One patient developed bilateral femur fractures of the same type.

Findings:

Bisphosphonate therapy may contribute to the development of stress femur fractures.
Radiological findings can include cortical thickening or spontaneous fracture patterns.
The fractures appear to be a specific type of stress injury.

Implications:

Discontinuation of bisphosphonate therapy is advised for patients presenting with these femur fractures.
Preventive nailing should be considered for patients with bilateral femur fractures.
Further research is needed to understand the mechanism and incidence of this side effect.